Thursday, April 11, 2013

How Chrono24 Helps Bring Order To The Chaotic Watch Market

Screen Shot 2013-04-09 at 10.08.03 AMAs TC's resident watch lover, I often find myself browsing the horology forums while alone, scantily-clad, and drunk. However, in this era of connoisseur-nets and always-conntected trade, there are few bargains to be found and even fewer ways to find exactly what you want. That's where Chrono24.com comes in. Founded by serial entrepreneurs Tim Stracke and Dirk Schwartz, the site has been live since 2003 but has just recently streamlined its operations to offer a sort of watch search engine that allows users to find timepieces of note from almost anywhere in the world.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/Xv6u0q5HZ0M/

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Wednesday, April 10, 2013

Ondi Timoner Launches Kickstarter Campaign to Train Artists in ''Disruptive'' Technology

By Steve Pond

LOS ANGELES (TheWrap.com) - Award-winning documentary director Ondi Timoner, whose films include the Sundance champs "Dig!" and "We Live in Public," is launching her first crowd-funding campaign to finance an extension of her A Total Disruption website, which chronicles innovators and entrepreneurs in the tech world.

"You can't just be an artist now," Timoner told TheWrap this week. "You have to be an artist-entrepreneur, and we want to set up a resource to show content creators how it can be done."

For the website, Timoner has produced more than 50 episodes dealing with innovators including Reddit's Steve Huffman and Alexis Ohanian, BitTorrent's Bram Cohen, LinkedIn's Reid Hoffman, Instagram's Kevin Systrom and musician Amanda Palmer, who will be the subject of a new series of episodes.

"We want to answer some basic questions," said Timoner. "How do you finance and distribute films and music and artwork? How do you collaborate? How do you use technology to directly connect with your fan base?"

Part of the reason for launching the website, she said, is because technology and culture move too fast for her to spend a long time doing interviews and collecting material, and then make a feature documentary about the subject.

"I can wait years and do a big movie, or I can film it and release it as I'm going," she said.

The Kickstarter campaign, which has a goal of $96,000, will help her finish episodes that have already been shot, as well as film new episodes chronicling innovators and entrenpreneurs in the tech world and the intersection of technology, art and entertainment.

The campaign will also fund putting Timoner's entire archive of 300 interviews online, in a searchable database and archive that can be used by content creators and others looking to explore the opportunities made possible by new technology.

The campaign will go live at 8 a.m. on Tuesday morning. Rewards for contributors will include Skype calls with selected entrepreneurs, original artwork from Shepard Fairey and the opportunity to join Timoner and Palmer for dinner and a shoot.

A Total Disruption grew out of the research Timoner did for the 2009 documentary "We Live in Public," which followed the eccentric dot-com millionaire Josh Harris and won the Grand Jury Prize.

Forced to distribute the film independently after companies became skittish in the wake of the '08 stock market crash, Timoner said she learned of the impact of online platforms and new technology in reaching an audience.

The archive will eventually be available for a small subscription fee, she said. A Total Disruption also plans to develop online courses for content creators looking to embrace the new paradigms.

"We have more power in our pockets than we had on all the computers in the world five years ago," she said. "The disruption is happening now, and it's happening in real time."

Source: http://news.yahoo.com/ondi-timoner-launches-kickstarter-campaign-train-artists-disruptive-194834454.html

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NYC museum gets renowned $1B Cubist collection

NEW YORK (AP) ? New York City's Metropolitan Museum of Art is getting a billion-dollar Cubist collection it says will "transform" it.

The museum announced Tuesday cosmetics executive and philanthropist Leonard Lauder has pledged his renowned collection of Cubist works.

The collection of 78 works includes pieces from Pablo Picasso, Georges Braque, Juan Gris and Fernand Leger and is considered one of the most pre-eminent Cubism collections in the world. It's valued at more than $1 billion.

Museum Director Thomas Campbell says the gift is "truly transformational" and will fill in a critical area in the museum's collection.

The Lauder collection is expected to be presented in an exhibition opening in the fall of 2014.

The museum says a new research center for modern art will be created at the museum.

Source: http://news.yahoo.com/nyc-met-museum-gets-renowned-1b-cubist-collection-000345871.html

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Tuesday, April 9, 2013

Margaret Thatcher, RIP (Powerlineblog)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/297503294?client_source=feed&format=rss

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Vaccine adjuvant uses host DNA to boost pathogen recognition

Monday, April 8, 2013

Aluminum salts, or alum, have been injected into billions of people as an adjuvant to make vaccines more effective. No one knows, however, how they boost the immune response. In the March 19, 2013, issue of the Proceedings of the National Academy of Sciencesresearchers at National Jewish Health continue unraveling the mystery of adjuvants with a report that host DNA coats the alum adjuvant and induces two crucial cells to interact twice as long during the initial stimulation of the adaptive immune system.

"Alum makes T cells take a longer look at the antigen, which produces a better immune response," said Philippa Marrack, PhD, senior author and professor of immunology at National Jewish Health. "Understanding how adjuvants work could help us make more effective vaccines. That is very important. Vaccines have saved millions of lives and been among the greatest advances in medical history."

Live vaccines, containing weakened forms of an infectious organism, generally work fine by themselves. But vaccines containing dead organisms (inactivated vaccines) or pieces of the infectious organisms or their toxins (acellular or recombinant vaccines) generally need adjuvants to boost their effectiveness. Aluminum salts, known as alum, are the only adjuvant approved for use in the United States for routine preventive vaccines.

Adjuvants were first discovered as the result of empirical experiments with tetanus early in the 20th century. They have been widely used in many vaccines since the 1940s, including the Diphtheria/Tetanus/Pertussis (DtaP), Hepatitis, Haemophilus influenzae (Hib), typhoid and some flu vaccines. No one fully understands why adjuvants boost the effectiveness of nonliving vaccines.

Recently a Belgian team showed that DNA is involved in the adjuvant effect. When they administered a vaccine with adjuvant and DNase, an enzyme that digests DNA, the vaccine was less effective. The National Jewish Health team built on those findings to reveal the role that DNA plays.

The National Jewish Health team had previously shown that the process starts with a series of events similar to those that initiate responses to bacterial infections. Neutrophils, and other early responders in the immune system, flood into a site of potential infection, attack the foreign agent, in this case the alum vaccine, then quickly die in massive numbers.

Upon death the neutrophils release large amounts of DNA, which uncoils from its chromatin spools and acts somewhat like a net to entangle the foreign agent. Other cells then engulf the DNA-alum-vaccine complex. These antigen-presenting cells display small fragments of the vaccine on their surfaces for T-cells to recognize. T-cells drive the adaptive immune response, the one that recognizes and attacks the specific infectious agent, as opposed to the more general innate immune response.

T-cells are also the basis for effective vaccines. Some T-cells, and the B-cells stimulated by the T-cells, transform into memory cells once the infection has been cleared. Those memory cells help mount a quicker and stronger immune response if they see that organism again.

The National Jewish Health team showed that the DNA coating the adjuvant doubles the time that the T-cell engages the vaccine fragment on the surface of the antigen-presenting cell. When they added DNase to digest DNA, the T-cell engaged the vaccine fragment half as long, and the vaccine was less effective. Several of the findings were made possible by an innovative use of multi-photon microscopy to film the interaction of T-cells and antigen-presenting cells.

"The DNA makes the antigen-presenting cell stickier," said Amy McKee, PhD, Instructor at the University of Colorado, and lead author of the paper. "We believe that extended engagement provides a stronger signal to the T-cell, which makes the immune response more robust."

The researchers are not sure exactly what makes the antigen-presenting cell 'stickier.' When that an antigen-presenting cell engulfs free-floating DNA, the researchers believe it recognizes that something is amiss (DNA should not normally be floating around outside an intact cell nucleus) and becomes more activated. It may respond with an additional co-receptor to engage the T-cell or release a molecule that stimulates the T-cell. The researchers are now working to understand that process.

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National Jewish Health: http://www.nationaljewish.org/

Thanks to National Jewish Health for this article.

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Source: http://www.labspaces.net/127622/Vaccine_adjuvant_uses_host_DNA_to_boost_pathogen_recognition

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Can Rebel Wilson Be Movie Awards Host And Winner?

On Sunday, 'Pitch Perfect' star faces Ezra Miller, Quvenzhané Wallis and more noobs for Breakthrough Performance prize.
By Kevin P. Sullivan


Ezra Miller and Rebel Wilson
Photo: MTV / Getty Images

Source: http://www.mtv.com/news/articles/1705125/rebel-wilson-movie-awards-host-winner.jhtml

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Newbie Social Gaming App WriteOn! Gets An Indiegogo Campaign To Raise Marketing Money

writeonApp developer golden fingers has taken to Indiegogo to raise cash for its first app: a social game called WriteOn!. The crowdfunding campaign is not to fund the creation of the app itself -- which is already available for (free) download on the App Store. Rather the developers are aiming to raise $3,000 to $5,000 to pay for marketing the app.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/4zPXC2drobY/

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